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Current Issue of Nature


Volume 560 Issue 7717, 9 August 2018

Volume 560 Issue 7717, 9 August 2018

Volume 560 Issue 7717

Brain drain

The task of removing waste products such as cellular debris and toxic molecules from the body’s tissues is performed by lymphatic vessels. In this week’s issue, Jonathan Kipnis and his colleagues reveal that the brain also makes use of this system, by moving macromolecular waste in cerebral fluids to be drained through lymphatic vessels located within the meninges — the membranes that cover the brain. They find that, in normal mice, cognitive function is reduced if the meningeal lymphatics become impaired. The researchers also show that ageing damages the lymphatics and that restoring their function is associated with recovered ‘brain cleansing’ and improved memory. Working with a mouse model for Alzheimer’s disease, the team reveals that if the meningeal lymphatic vessels are disrupted, clearance of the protein amyloid-β is impaired leading to accumulation in the brain, which worsens the amyloid pathology. The team suggests that targeting decline in the meningeal lymphatic system could be a useful therapeutic route to help combat age-related cognitive dysfunction.

Cover image: Ella Marushchenko and Elina Karimullina /Ella Maru Studio

This Week

News in Focus

Comment

Technology

Careers

Futures

  • Futures |

    Time to say goodbye.

    • S. R. Algernon

Research

    News & Views

  • News & Views |

    An approach has been developed for incorporating optoelectronic devices into polymer fibres, which can be woven into fabrics. Such materials could have applications in both telecommunication and health monitoring.

    • Walter Margulis
  • News & Views |

    Better treatments are needed for the neglected tropical disease leishmaniasis. The development of a compound that tackles the disease in mice, and the identification of the protein it targets, offer a way forward.

    • Carolina M. C. Catta-Preta
    •  & Jeremy C. Mottram
  • News & Views |

    The electric polarization of materials called ferroelectrics is often suppressed by an internal electric field, limiting uses for these materials. The discovery of a thin-film ferroelectric that is resistant to this field represents a major advance.

    • Turan Birol
  • News & Views |

    In materials known as graphene nanoribbons, topological states can be precisely engineered and probed, providing an experimental platform for studying electronic topology.

    • Katharina J. Franke
    •  & Felix von Oppen
  • News & Views |

    Activation of the inflammasome protein complex in immune cells is a key step that triggers an innate immune response. It emerges that the synthesis and oxidation of mitochondrial DNA drives this activation step.

    • Michael P. Murphy
  • Brief Communications Arising

  • Brief Communications Arising |

    • Fatwa Adikusuma
    • , Sandra Piltz
    • , Mark A. Corbett
    • , Michelle Turvey
    • , Shaun R. McColl
    • , Karla J. Helbig
    • , Michael R. Beard
    • , James Hughes
    • , Richard T. Pomerantz
    •  & Paul Q. Thomas
  • Brief Communications Arising |

    • Hong Ma
    • , Nuria Marti-Gutierrez
    • , Sang-Wook Park
    • , Jun Wu
    • , Tomonari Hayama
    • , Hayley Darby
    • , Crystal Van Dyken
    • , Ying Li
    • , Amy Koski
    • , Dan Liang
    • , Keiichiro Suzuki
    • , Ying Gu
    • , Jianhui Gong
    • , Xun Xu
    • , Riffat Ahmed
    • , Yeonmi Lee
    • , Eunju Kang
    • , Dongmei Ji
    • , A-Reum Park
    • , Daesik Kim
    • , Sang-Tae Kim
    • , Stephen B. Heitner
    • , David Battaglia
    • , Sacha A. Krieg
    • , David M. Lee
    • , Diana H. Wu
    • , Don P. Wolf
    • , Paula Amato
    • , Sanjiv Kaul
    • , Juan Carlos Izpisua Belmonte
    • , Jin-Soo Kim
    •  & Shoukhrat Mitalipov
  • Articles

  • Article |

    Coherent coupling between a three-electron spin qubit and single photons in a microwave resonator is demonstrated, which, unlike previous demonstrations, does not require ferromagnetic components near the qubit.

    • A. J. Landig
    • , J. V. Koski
    • , P. Scarlino
    • , U. C. Mendes
    • , A. Blais
    • , C. Reichl
    • , W. Wegscheider
    • , A. Wallraff
    • , K. Ensslin
    •  & T. Ihn
  • Article |

    Meningeal lymphatic dysfunction promotes amyloid-β deposition in the meninges and worsens brain amyloid-β pathology, acting as an aggravating factor in Alzheimer’s disease and in age-associated cognitive decline; improving meningeal lymphatic function could help to prevent or delay age-associated neurological diseases.

    • Sandro Da Mesquita
    • , Antoine Louveau
    • , Andrea Vaccari
    • , Igor Smirnov
    • , R. Chase Cornelison
    • , Kathryn M. Kingsmore
    • , Christian Contarino
    • , Suna Onengut-Gumuscu
    • , Emily Farber
    • , Daniel Raper
    • , Kenneth E. Viar
    • , Romie D. Powell
    • , Wendy Baker
    • , Nisha Dabhi
    • , Robin Bai
    • , Rui Cao
    • , Song Hu
    • , Stephen S. Rich
    • , Jennifer M. Munson
    • , M. Beatriz Lopes
    • , Christopher C. Overall
    • , Scott T. Acton
    •  & Jonathan Kipnis
  • Article |

    A series of compounds are discovered for the treatment of visceral leishmaniasis, and cdc2-related kinase 12 (CRK12) is identified as the probable primary drug target.

    • Susan Wyllie
    • , Michael Thomas
    • , Stephen Patterson
    • , Sabrinia Crouch
    • , Manu De Rycker
    • , Rhiannon Lowe
    • , Stephanie Gresham
    • , Michael D. Urbaniak
    • , Thomas D. Otto
    • , Laste Stojanovski
    • , Frederick R. C. Simeons
    • , Sujatha Manthri
    • , Lorna M. MacLean
    • , Fabio Zuccotto
    • , Nadine Homeyer
    • , Hannah Pflaumer
    • , Markus Boesche
    • , Lalitha Sastry
    • , Paul Connolly
    • , Sebastian Albrecht
    • , Matt Berriman
    • , Gerard Drewes
    • , David W. Gray
    • , Sonja Ghidelli-Disse
    • , Susan Dixon
    • , Jose M. Fiandor
    • , Paul G. Wyatt
    • , Michael A. J. Ferguson
    • , Alan H. Fairlamb
    • , Timothy J. Miles
    • , Kevin D. Read
    •  & Ian H. Gilbert
  • Article |

    New mitochondrial DNA synthesis links the priming and activation of the NLRP3 inflammasome.

    • Zhenyu Zhong
    • , Shuang Liang
    • , Elsa Sanchez-Lopez
    • , Feng He
    • , Shabnam Shalapour
    • , Xue-jia Lin
    • , Jerry Wong
    • , Siyuan Ding
    • , Ekihiro Seki
    • , Bernd Schnabl
    • , Andrea L. Hevener
    • , Harry B. Greenberg
    • , Tatiana Kisseleva
    •  & Michael Karin
  • Letters

  • Letter |

    A topologically engineered graphene nanoribbon superlattice is presented that hosts a one-dimensional array of half-filled, in-gap localized electronic states, enabling band engineering.

    • Daniel J. Rizzo
    • , Gregory Veber
    • , Ting Cao
    • , Christopher Bronner
    • , Ting Chen
    • , Fangzhou Zhao
    • , Henry Rodriguez
    • , Steven G. Louie
    • , Michael F. Crommie
    •  & Felix R. Fischer
  • Letter |

    Graphene nanoribbons are used to design robust nanomaterials with controlled periodic coupling of topological boundary states to create quasi-one-dimensional trivial and non-trivial electronic quantum phases.

    • Oliver Gröning
    • , Shiyong Wang
    • , Xuelin Yao
    • , Carlo A. Pignedoli
    • , Gabriela Borin Barin
    • , Colin Daniels
    • , Andrew Cupo
    • , Vincent Meunier
    • , Xinliang Feng
    • , Akimitsu Narita
    • , Klaus Müllen
    • , Pascal Ruffieux
    •  & Roman Fasel
  • Letter |

    A scalable thermal drawing process is used to integrate light-emitting and photodetecting diodes into textile-ready polymer fibres, which can be woven into fabrics with possible optical communication and health monitoring applications.

    • Michael Rein
    • , Valentine Dominique Favrod
    • , Chong Hou
    • , Tural Khudiyev
    • , Alexander Stolyarov
    • , Jason Cox
    • , Chia-Chun Chung
    • , Chhea Chhav
    • , Marty Ellis
    • , John Joannopoulos
    •  & Yoel Fink
  • Letter |

    Similarities between the patterning of the lateral plate in Ciona and of the neural plate ectoderm in vertebrates indicate that compartmentalization of the lateral plate ectoderm preceded the advent of vertebrates.

    • Ryoko Horie
    • , Alex Hazbun
    • , Kai Chen
    • , Chen Cao
    • , Michael Levine
    •  & Takeo Horie
  • Letter |

    Metagenomic, chemical and biomass analyses of topsoil samples from around the world reveal spatial and environmental trends in microbial community composition and genetic diversity.

    • Mohammad Bahram
    • , Falk Hildebrand
    • , Sofia K. Forslund
    • , Jennifer L. Anderson
    • , Nadejda A. Soudzilovskaia
    • , Peter M. Bodegom
    • , Johan Bengtsson-Palme
    • , Sten Anslan
    • , Luis Pedro Coelho
    • , Helery Harend
    • , Jaime Huerta-Cepas
    • , Marnix H. Medema
    • , Mia R. Maltz
    • , Sunil Mundra
    • , Pål Axel Olsson
    • , Mari Pent
    • , Sergei Põlme
    • , Shinichi Sunagawa
    • , Martin Ryberg
    • , Leho Tedersoo
    •  & Peer Bork
  • Letter |

    Mitochondrial double-stranded RNA can induce an interferon response if released into the cytoplasm, but self-recognition is prevented by SUV3 helicase and PNPase exoribonuclease.

    • Ashish Dhir
    • , Somdutta Dhir
    • , Lukasz S. Borowski
    • , Laura Jimenez
    • , Michael Teitell
    • , Agnès Rötig
    • , Yanick J. Crow
    • , Gillian I. Rice
    • , Darragh Duffy
    • , Christelle Tamby
    • , Takayuki Nojima
    • , Arnold Munnich
    • , Manuel Schiff
    • , Claudia Ribeiro de Almeida
    • , Jan Rehwinkel
    • , Andrzej Dziembowski
    • , Roman J. Szczesny
    •  & Nicholas J. Proudfoot
  • Letter |

    Human neural stem cells from the subventricular zone are identified as the cells of origin that contain the driver mutations for glioblastomas.

    • Joo Ho Lee
    • , Jeong Eun Lee
    • , Jee Ye Kahng
    • , Se Hoon Kim
    • , Jun Sung Park
    • , Seon Jin Yoon
    • , Ji-Yong Um
    • , Woo Kyeong Kim
    • , June-Koo Lee
    • , Junseong Park
    • , Eui Hyun Kim
    • , Ji-Hyun Lee
    • , Joon-Hyuk Lee
    • , Won-Suk Chung
    • , Young Seok Ju
    • , Sung-Hong Park
    • , Jong Hee Chang
    • , Seok-Gu Kang
    •  & Jeong Ho Lee
  • Letter |

    Selective inhibitors of KAT6A and KAT6B inhibit MYST-catalysed histone acetylation, induce cell cycle exit and cellular senescence without causing DNA damage, and arrest lymphoma progression in mouse models.

    • Jonathan B. Baell
    • , David J. Leaver
    • , Stefan J. Hermans
    • , Gemma L. Kelly
    • , Margs S. Brennan
    • , Natalie L. Downer
    • , Nghi Nguyen
    • , Johannes Wichmann
    • , Helen M. McRae
    • , Yuqing Yang
    • , Ben Cleary
    • , H. Rachel Lagiakos
    • , Stephen Mieruszynski
    • , Guido Pacini
    • , Hannah K. Vanyai
    • , Maria I. Bergamasco
    • , Rose E. May
    • , Bethany K. Davey
    • , Kimberly J. Morgan
    • , Andrew J. Sealey
    • , Beinan Wang
    • , Natasha Zamudio
    • , Stephen Wilcox
    • , Alexandra L. Garnham
    • , Bilal N. Sheikh
    • , Brandon J. Aubrey
    • , Karen Doggett
    • , Matthew C. Chung
    • , Melanie de Silva
    • , John Bentley
    • , Pat Pilling
    • , Meghan Hattarki
    • , Olan Dolezal
    • , Matthew L. Dennis
    • , Hendrik Falk
    • , Bin Ren
    • , Susan A. Charman
    • , Karen L. White
    • , Jai Rautela
    • , Andrea Newbold
    • , Edwin D. Hawkins
    • , Ricky W. Johnstone
    • , Nicholas D. Huntington
    • , Thomas S. Peat
    • , Joan K. Heath
    • , Andreas Strasser
    • , Michael W. Parker
    • , Gordon K. Smyth
    • , Ian P. Street
    • , Brendon J. Monahan
    • , Anne K. Voss
    •  & Tim Thomas
  • Letter |

    A cryo-electron microscopy structure of human dynamin-1 demonstrates conformational changes and sheds light on the fission of membranes during endocytosis.

    • Leopold Kong
    • , Kem A. Sochacki
    • , Huaibin Wang
    • , Shunming Fang
    • , Bertram Canagarajah
    • , Andrew D. Kehr
    • , William J. Rice
    • , Marie-Paule Strub
    • , Justin W. Taraska
    •  & Jenny E. Hinshaw
  • Letter |

    A cryo-electron microscopy structure of the mammalian mitochondrial translation initiation complex reveals unique features that are necessary to initiate mitochondrial translation and highlights a possible membrane-targeting peptide.

    • Eva Kummer
    • , Marc Leibundgut
    • , Oliver Rackham
    • , Richard G. Lee
    • , Daniel Boehringer
    • , Aleksandra Filipovska
    •  & Nenad Ban

Amendments & Corrections