This page is brought to you by Brian Golding (Golding@McMaster.CA) and is copied locally here to speed your access. To go to the original page (should you find something interesting or should you wish to follow links) click on

Current Issue of Nature


Volume 564 Issue 7734, 6 December 2018

Volume 564 Issue 7734, 6 December 2018

Volume 564 Issue 7734

Cellular ushers

In vertebrates, haematopoietic stem and progenitor cells (HSPCs) act as the source for all of the blood cells needed over an organism’s lifespan. HSPCs emerge from endothelial cells in the dorsal aorta of developing embryos and then migrate to dedicated niches where they are stored ready to generate blood cells. In this week’s issue, Weijun Pan and colleagues shed light on the mechanism by which HSPCs are shuttled to their destination. Working with zebrafish embryos, the researchers found that macrophage-like cells act as ushers, guiding the HSPCs to their destination and helping to retain them in their niche microenvironments.

Credit: Pablo Bou Mira /Alamy

This Week

News in Focus

Comment

Technology

    Technology Feature

  • Technology Feature |

    Techniques that render tissues as clear as glass and swell them to several times their original size are giving unprecedented access to the inner workings of biological systems.

    • Michael Eisenstein

Careers

Futures

Research

    News & Views

  • News & Views |

    A natural chemical reaction that occurs below the sea floor makes the amino acid tryptophan without biological input. This finding reveals a process that might have helped life on Earth to begin.

    • John A. Baross
  • News & Views |

    Magnetic materials can host a range of structures called spin textures. Two such textures — a meron and an antimeron — have been observed experimentally for the first time, in a material known as a chiral magnet.

    • Seonghoon Woo
  • News & Views |

    Chloroplast organelles in plant cells are thought to have evolved from bacterial cells. It emerges that the protein-import system in chloroplasts arose from components that export proteins out of bacteria.

    • Danny J. Schnell
  • News & Views |

    Measurements of the strength of interactions between the Higgs boson and other particles test the current model of particle physics. A key part of this model has been confirmed by observing the most common decay of the Higgs boson.

    • Boris Tuchming
  • News & Views |

    Low oxygen levels are a hallmark of expanding fat tissue in obesity, and can lead to type 2 diabetes. In addition to a lack of adequate blood supply, increased oxygen demand in fat cells now emerges as being key to this harmful state.

    • Nolwenn Joffin
    •  & Philipp E. Scherer
  • News & Views |

    Ammonia emissions harm humans and the environment. An analysis shows that satellites can locate sources precisely, and could thus help to monitor compliance with international agreements to limit such emissions.

    • Mark A. Sutton
    •  & Clare M. Howard
  • News & Views |

    Intrinsic and extrinsic cues drive dynamic processes that control cell fate during organ development. A study of mouse and human cells reveals how these inputs affect cells that make the essential hormone insulin.

    • Francesca M. Spagnoli
  • Brief Communications Arising

  • Brief Communications Arising |

    • J. B. Berger
    • , H. N. G. Wadley
    •  & R. M. McMeeking
  • Articles

  • Article |

    Accounting for meltwater from the Antarctic Ice Sheet in simulations of global climate leads to substantial changes in future climate projections and identifies a potential feedback mechanism that exacerbates melting.

    • Ben Bronselaer
    • , Michael Winton
    • , Stephen M. Griffies
    • , William J. Hurlin
    • , Keith B. Rodgers
    • , Olga V. Sergienko
    • , Ronald J. Stouffer
    •  & Joellen L. Russell
  • Article |

    High-resolution imaging techniques show that aromatic amino acids such as tryptophan formed abiotically and were subsequently preserved at depth beneath the Atlantis Massif of the Mid-Atlantic Ridge, supporting the hydrothermal theory for the origin of life.

    • Bénédicte Ménez
    • , Céline Pisapia
    • , Muriel Andreani
    • , Frédéric Jamme
    • , Quentin P. Vanbellingen
    • , Alain Brunelle
    • , Laurent Richard
    • , Paul Dumas
    •  & Matthieu Réfrégiers
  • Article | | open

    Genomic, epigenomic and transcriptomic data derived from the Mediterranean amphioxus (Branchiostoma lanceolatum) provide insights into the evolution of the genomic regulatory landscape of chordates.

    • Ferdinand Marlétaz
    • , Panos N. Firbas
    • , Ignacio Maeso
    • , Juan J. Tena
    • , Ozren Bogdanovic
    • , Malcolm Perry
    • , Christopher D. R. Wyatt
    • , Elisa de la Calle-Mustienes
    • , Stephanie Bertrand
    • , Demian Burguera
    • , Rafael D. Acemel
    • , Simon J. van Heeringen
    • , Silvia Naranjo
    • , Carlos Herrera-Ubeda
    • , Ksenia Skvortsova
    • , Sandra Jimenez-Gancedo
    • , Daniel Aldea
    • , Yamile Marquez
    • , Lorena Buono
    • , Iryna Kozmikova
    • , Jon Permanyer
    • , Alexandra Louis
    • , Beatriz Albuixech-Crespo
    • , Yann Le Petillon
    • , Anthony Leon
    • , Lucie Subirana
    • , Piotr J. Balwierz
    • , Paul Edward Duckett
    • , Ensieh Farahani
    • , Jean-Marc Aury
    • , Sophie Mangenot
    • , Patrick Wincker
    • , Ricard Albalat
    • , Èlia Benito-Gutiérrez
    • , Cristian Cañestro
    • , Filipe Castro
    • , Salvatore D’Aniello
    • , David E. K. Ferrier
    • , Shengfeng Huang
    • , Vincent Laudet
    • , Gabriel A. B. Marais
    • , Pierre Pontarotti
    • , Michael Schubert
    • , Hervé Seitz
    • , Ildiko Somorjai
    • , Tokiharu Takahashi
    • , Olivier Mirabeau
    • , Anlong Xu
    • , Jr-Kai Yu
    • , Piero Carninci
    • , Juan Ramon Martinez-Morales
    • , Hugues Roest Crollius
    • , Zbynek Kozmik
    • , Matthew T. Weirauch
    • , Jordi Garcia-Fernàndez
    • , Ryan Lister
    • , Boris Lenhard
    • , Peter W. H. Holland
    • , Hector Escriva
    • , Jose Luis Gómez-Skarmeta
    •  & Manuel Irimia
  • Letters

  • Letter |

    Early results from the COSINE-100 experiment—designed to test a much-debated claim of the detection of a dark-matter signal—show no indications of dark matter, providing evidence against the previous claim.

    • Govinda Adhikari
    • , Pushparaj Adhikari
    • , Estella Barbosa de Souza
    • , Nelson Carlin
    • , Seonho Choi
    • , Mitra Djamal
    • , Anthony C. Ezeribe
    • , Chang Hyon Ha
    • , Insik Hahn
    • , Antonia J. F. Hubbard
    • , Eunju Jeon
    • , Jay Hyun Jo
    • , Hanwool Joo
    • , Woon Gu Kang
    • , Woosik Kang
    • , Matthew Kauer
    • , Bonghee Kim
    • , Hongjoo Kim
    • , Hyounggyu Kim
    • , Kyungwon Kim
    • , Nam Young Kim
    • , Sun Kee Kim
    • , Yeongduk Kim
    • , Yong-Hamb Kim
    • , Young Ju Ko
    • , Vitaly A. Kudryavtsev
    • , Hyun Su Lee
    • , Jaison Lee
    • , Jooyoung Lee
    • , Moo Hyun Lee
    • , Douglas S. Leonard
    • , Warren A. Lynch
    • , Reina H. Maruyama
    • , Frederic Mouton
    • , Stephen L. Olsen
    • , Byungju Park
    • , Hyang Kyu Park
    • , Hyeonseo Park
    • , Jungsic Park
    • , Kangsoon Park
    • , Walter C. Pettus
    • , Hafizh Prihtiadi
    • , Sejin Ra
    • , Carsten Rott
    • , Andrew Scarff
    • , Keon Ah Shin
    • , Neil J. C. Spooner
    • , William G. Thompson
    • , Liang Yang
    •  & Seok Hyun Yong
  • Letter |

    Improved techniques allow the measurement of a frequency difference with an uncertainty of the order of 10–19 between two independent atomic optical lattice clocks, suggesting that they may be able to improve state-of-the-art geodetic techniques.

    • W. F. McGrew
    • , X. Zhang
    • , R. J. Fasano
    • , S. A. Schäffer
    • , K. Beloy
    • , D. Nicolodi
    • , R. C. Brown
    • , N. Hinkley
    • , G. Milani
    • , M. Schioppo
    • , T. H. Yoon
    •  & A. D. Ludlow
  • Letter |

    A refractive lens and a refractive prism for extreme-ultraviolet radiation have been developed that use the deflection of the radiation in an inhomogeneous jet of atoms.

    • L. Drescher
    • , O. Kornilov
    • , T. Witting
    • , G. Reitsma
    • , N. Monserud
    • , A. Rouzée
    • , J. Mikosch
    • , M. J. J. Vrakking
    •  & B. Schütte
  • Letter |

    Satellite observations reveal over 200 ammonia hotspots associated with agricultural and industrial point sources, which emit much larger quantities of ammonia to the atmosphere than previously thought.

    • Martin Van Damme
    • , Lieven Clarisse
    • , Simon Whitburn
    • , Juliette Hadji-Lazaro
    • , Daniel Hurtmans
    • , Cathy Clerbaux
    •  & Pierre-François Coheur
  • Letter |

    Ice-core-derived melt records reveal that atmospheric warming has recently intensified Greenland ice-sheet surface melt and runoff to levels that are exceptional over at least the last 350 years.

    • Luke D. Trusel
    • , Sarah B. Das
    • , Matthew B. Osman
    • , Matthew J. Evans
    • , Ben E. Smith
    • , Xavier Fettweis
    • , Joseph R. McConnell
    • , Brice P. Y. Noël
    •  & Michiel R. van den Broeke
  • Letter |

    Single-cell analysis reveals that interactions with the extracellular matrix via integrin α5 and mechanotransducer YAP1 determine whether pancreatic progenitors develop along the duct or endocrine lineages.

    • Anant Mamidi
    • , Christy Prawiro
    • , Philip A. Seymour
    • , Kristian Honnens de Lichtenberg
    • , Abigail Jackson
    • , Palle Serup
    •  & Henrik Semb
  • Letter |

    In zebrafish embryogenesis, nascent haematopoietic stem and progenitor cells (HSPCs), homing to a vascular niche for retention, are ushered by patrolling and guiding macrophages through integrin-mediated cell-cell recognition.

    • Dantong Li
    • , Wenzhi Xue
    • , Mei Li
    • , Mei Dong
    • , Jianwei Wang
    • , Xianda Wang
    • , Xiyue Li
    • , Kai Chen
    • , Wenjuan Zhang
    • , Shuang Wu
    • , Yingqi Zhang
    • , Lei Gao
    • , Yujie Chen
    • , Jianfeng Chen
    • , Bo O. Zhou
    • , Yi Zhou
    • , Xuebiao Yao
    • , Lin Li
    • , Dianqing Wu
    •  & Weijun Pan
  • Letter |

    PD-1 undergoes internalization, FBXO38-mediated ubiquitination and proteasome degradation in activated T cells, and inhibition of this pathway dampens anti-tumour immunity of T cells.

    • Xiangbo Meng
    • , Xiwei Liu
    • , Xingdong Guo
    • , Shutan Jiang
    • , Tingting Chen
    • , Zhiqiang Hu
    • , Haifeng Liu
    • , Yibing Bai
    • , Manman Xue
    • , Ronggui Hu
    • , Shao-cong Sun
    • , Xiaolong Liu
    • , Penghui Zhou
    • , Xiaowu Huang
    • , Lai Wei
    • , Wei Yang
    •  & Chenqi Xu
  • Letter |

    Stella, a factor essential for female fertility, protects the oocyte methylome in mice by suppressing de novo DNA methylation mediated by the DNA methyltransferase DNMT1.

    • Yingfeng Li
    • , Zhuqiang Zhang
    • , Jiayu Chen
    • , Wenqiang Liu
    • , Weiyi Lai
    • , Baodong Liu
    • , Xiang Li
    • , Liping Liu
    • , Shaohua Xu
    • , Qiang Dong
    • , Mingzhu Wang
    • , Xiaoya Duan
    • , Jiajun Tan
    • , Yong Zheng
    • , Pumin Zhang
    • , Guoping Fan
    • , Jiemin Wong
    • , Guo-Liang Xu
    • , Zhigao Wang
    • , Hailin Wang
    • , Shaorong Gao
    •  & Bing Zhu

Amendments & Corrections

Spotlight

  • Spotlight |

    Cell biology

    Terminology and concepts from computer science and engineering are becoming more common in biology labs as scientists re-engineer the activity of cells for specific applications.

Newsletter Get the most important science stories of the day, free in your inbox. Sign up for Nature Briefing