Subject: PLOS Genetics Volume 15(10) October 2019 Content-Type: text/html; charset="utf-8" Content-Transfer-Encoding: 8bit

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New Articles in PLOS Genetics

PUBLISHED: October 01, 2019 to October 31, 2019

Editorial

Evaluating the strength of genetic results: Risks and responsibilities

Topic Page

Viral quasispecies

Perspective

Mck1 kinase is a new player in the DNA damage checkpoint pathway

Research Articles

Kinetochore-associated Stu2 promotes chromosome biorientation in vivo

TSEN54 missense variant in Standard Schnauzers with leukodystrophy

Histone deposition promotes recombination-dependent replication at arrested forks

Manipulating mtDNA in vivo reprograms metabolism via novel response mechanisms

HRPK-1, a conserved KH-domain protein, modulates microRNA activity during Caenorhabditis elegans development

Differential Requirements for the RAD51 Paralogs in Genome Repair and Maintenance in Human Cells

The effects of manipulating levels of replication initiation factors on origin firing efficiency in yeast

Spatiotemporal cytoskeleton organizations determine morphogenesis of multicellular trichomes in tomato

Tnni3k alleles influence ventricular mononuclear diploid cardiomyocyte frequency

Low affinity binding sites in an activating CRM mediate negative autoregulation of the Drosophila Hox gene Ultrabithorax

Optimizing clinical exome design and parallel gene-testing for recessive genetic conditions in preconception carrier screening: Translational research genomic data from 14,125 exomes

NusG prevents transcriptional invasion of H-NS-silenced genes

Loss of thymidine kinase 1 inhibits lung cancer growth and metastatic attributes by reducing GDF15 expression

Bacillus subtilis PgcA moonlights as a phosphoglucosamine mutase in support of peptidoglycan synthesis

Ataxin2 functions via CrebA to mediate Huntingtin toxicity in circadian clock neurons

Bayesian multivariate reanalysis of large genetic studies identifies many new associations

A functional regulatory variant of MYH3 influences muscle fiber-type composition and intramuscular fat content in pigs

Centromeric SMC1 promotes centromere clustering and stabilizes meiotic homolog pairing

A novel system of bacterial cell division arrest implicated in horizontal transmission of an integrative and conjugative element

GPCR-mediated glucose sensing system regulates light-dependent fungal development and mycotoxin production

Genetic factors define CPO and CLO subtypes of nonsyndromicorofacial cleft

Genetic mapping of fitness determinants across the malaria parasite Plasmodium falciparum life cycle

Protease-associated import systems are widespread in Gram-negative bacteria

Metabolic effects of skeletal muscle-specific deletion of beta-arrestin-1 and -2 in mice

Biofilm-associated toxin and extracellular protease cooperatively suppress competitors in Bacillus subtilis biofilms

Mutations of the Bacillus subtilis YidC1 (SpoIIIJ) insertase alleviate stress associated with σM-dependent membrane protein overproduction

Nitrate-responsive OBP4-XTH9 regulatory module controls lateral root development in Arabidopsis thaliana

Local adaptation drives the diversification of effectors in the fungal wheat pathogen Parastagonospora nodorum in the United States

PilT and PilU are homohexameric ATPases that coordinate to retract type IVa pili

Macrophages fine tune satellite cell fate in dystrophic skeletal muscle of mdx mice

A small set of conserved genes, including sp5 and Hox, are activated by Wnt signaling in the posterior of planarians and acoels

CRISPR editing of sftb-1/SF3B1 in Caenorhabditis elegans allows the identification of synthetic interactions with cancer-related mutations and the chemical inhibition of splicing

Causal relationships between obesity and the leading causes of death in women and men

A RAPGEF6 variant constitutes a major risk factor for laryngeal paralysis in dogs

Dysregulation of STAT3 signaling is associated with endplate-oriented herniations of the intervertebral disc in Adgrg6 mutant mice

Duplicate divergence of two bacterial small heat shock proteins reduces the demand for Hsp70 in refolding of substrates

Paralog buffering contributes to the variable essentiality of genes in cancer cell lines

Splice variants of DOMINO control Drosophila circadian behavior and pacemaker neuron maintenance

The quorum sensing transcription factor AphA directly regulates natural competence in Vibrio cholerae

INX-18 and INX-19 play distinct roles in electrical synapses that modulate aversive behavior in Caenorhabditis elegans

The comprehensive role of E-cadherin in maintaining prostatic epithelial integrity during oncogenic transformation and tumor progression

Synergistic action of the transcription factors Krüppel homolog 1 and Hairy in juvenile hormone/Methoprene-tolerant-mediated gene-repression in the mosquito Aedes aegypti

MR-pheWAS with stratification and interaction: Searching for the causal effects of smoking heaviness identified an effect on facial aging

A missense mutation in SNRPE linked to non-syndromal microcephaly interferes with U snRNP assembly and pre-mRNA splicing

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